A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration.

#Transposons #Retrotransposons #SVA #XLinkedDystoniaParkinsonism #XDP #Neurodegeneration #Organoids #ShortTandemRepeats #Rloops #AntisenseNucleotides

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00583-2