Living with a Mechanical Mitral Valve and Warfarin: The Diet, the Biochemistry, and What Nobody Tells You Until Itโ€™s Too Late

What I wish someone had handed me on discharge day: the biochemistry of warfarin and vitamin K, the food atlas, the drug and herbal interactions, travel, and the daily operating procedure of life on warfarin with a mechanical mitral valve. Written engineer-to-engineer.

https://kemal.yaylali.uk/warfarin-vitamin-k-mechanical-mitral-valve/

๐—ช๐—ผ๐—ฟ๐—น๐—ฑ ๐—ง๐—ต๐—ฟ๐—ผ๐—บ๐—ฏ๐—ผ๐˜€๐—ถ๐˜€ ๐——๐—ฎ๐˜† โ€” ๐Ÿญ๐Ÿฏ ๐—ข๐—ฐ๐˜๐—ผ๐—ฏ๐—ฒ๐—ฟ ๐Ÿฎ๐Ÿฌ๐Ÿฎ๐Ÿฑ: "๐—™๐—ฟ๐—ผ๐—บ ๐—›๐—ฒ๐—ฎ๐—ฑ ๐˜๐—ผ ๐—ง๐—ผ๐—ฒ, ๐—ง๐—ฎ๐—ธ๐—ฒ ๐—–๐—ผ๐—ป๐˜๐—ฟ๐—ผ๐—น: ๐—ฃ๐—ฟ๐—ฒ๐˜ƒ๐—ฒ๐—ป๐˜ ๐—ง๐—ต๐—ฟ๐—ผ๐—บ๐—ฏ๐—ผ๐˜€๐—ถ๐˜€, ๐—ฃ๐—ฟ๐—ผ๐˜๐—ฒ๐—ฐ๐˜ ๐—ฌ๐—ผ๐˜‚๐—ฟ ๐—›๐—ฒ๐—ฎ๐—น๐˜๐—ต."

Thrombosis (blood clots) can block veins or arteries and lead to deep vein thrombosis, pulmonary embolism, heart attack, or stroke. Many risk factors are common and modifiable โ€” prolonged immobility, recent surgery, cancer, hormone therapy, obesity, smoking, and unmanaged chronic diseases โ€” so early recognition (leg swelling/pain, sudden shortness of breath, chest pain, sudden weakness or speech changes) and timely medical assessment save lives.

Take simple steps to reduce risk: stay active and hydrate during long travel, maintain a healthy weight, quit smoking, control diabetes and heart disease, use compression stockings when advised, and follow anticoagulant instructions carefully. Share this message so more people know the signs and preventive actions โ€” from head to toe, take control.

#WorldThrombosisDay #ThrombosisAwareness #PreventVTE #DVT #PulmonaryEmbolism #BloodClots #HeartHealth #StrokePrevention #TravelSafely #Anticoagulation #KnowTheSigns #SCABPharmacy

Iniciar tratamiento con #anticoagulante oral en los primeros 4 dรญas despuรฉs de un #EVC #isquรฉmico en un paciente con #FibrilaciรณnAuricular es seguro, y beneficia mรกs al paciente que iniciarlo despuรฉs (5-14 dรญas).

#OPTIMAS #CATALYST #Ischemic #Stroke #Anticoagulation #AtrialFibrillation

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02197-4/fulltext

#Anticoagulation and venous thromboembolism in patients aged 90โ€‰years and older

In very old patients, you may need different management for the same condition according to the initial clinical presentation.

In other words, one-fits-all does not work...

#Geriatrics #Aging #Care #Medical

https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jgs.18626

Use of #anticoagulation treatments for hospitalized #COVID patients decreased after #omicron. Patients more likely to get anticoagulation treatment included being older, being Black, obesity, length of hospital stay, being on a ventilator, being high risk, and being unvaccinated.

#TWiVTLDR 9/

En pacientes con #FibrilaciรณnAuricular que sufren un #EVC, la evidencia favorece el inicio temprano de #anticoagulaciรณn (en los primeros 2 dรญas) sobre el retraso de la misma.

#Stroke #AF #AtrialFibrillation #anticoagulation

https://www.nejm.org/doi/full/10.1056/NEJMoa2303048?query=featured_home

Should we delay #anticoagulation of #stroke in all patient because a frequentist analysis said so? Is this the way the clinician see things when making its decision?

#NEJM #NeuroCriticalCare

https://www.nejm.org/doi/full/10.1056/NEJMoa2303048

High-dose prophylactic #anticoagulation is (was?) affective to reduce the occurence of #thrombosis without impacting outcomes in #Covid hypoxemic failure

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2802821

#JAMAInternalMedicine #FOAMcc #CriticalCare

Effects of Anticoagulation Dosage in Patients with Hypoxemic COVID-19 Pneumonia

This randomized clinical trial compares the effects of high-dose, standard-dose, and therapeutic anticoagulation on mortality and/or disease duration among patients with hypoxemic COVID-19 pneumonia in 23 hospitals in France.

#FREEDOM #COVID #Anticoagulation Strategy Randomized Trial:

High-dose subcutaneous enoxaparin or oral apixaban โ€“ to inhibit thrombosis and progression of disease โ€“ can reduce deaths by 30%, intubations by 25% in hospitalized patients with pulmonary involvement but not yet in the #ICU, when compared to the standard treatment (low-dose anticoagulation).

https://medicalxpress.com/news/2023-03-high-dose-anticoagulation-intubations-survival-hospitalized.html

#SARSCoV2 @novid

High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation. These are the significant findings from the large-scale international "FREEDOM" trial, led by Valentin Fuster, MD, Ph.D., President of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, and General Director of the Spanish National Center for Cardiovascular Research (CNIC).