🗝️ Tor und 🏰 Schlüssel zur Wirkung von 🌱 #Cannabis 06

🔬🌱 #Studien an 🐭 #Tieren 🙄 haben vielversprechende Ergebnisse bei 🌩️ 🏥 #chronischentzündlichenErkrankungen des 🧠 #zentralenNervensystems und des Magen-Darm-Trakts sowie in der 🏥 🌱 #Antitumortherapie von 🤕 #Gliomen (spez. ☠️ #Hirntumor) geliefert.

https://medcan.ch/medizinische-informationen/ecs

#Medizin #Forschung #Wissenschaft #medicine #science #politics #health #Weedmob #FridaysforFUTURE #Hanfwissen #cancer #brain #antitumor #patent6630507 #neuroprotective

🗝️ Tor und 🏰 Schlüssel zur Wirkung von 🌱 #Cannabis 06

🔬🌱 #Studien an 🐭 #Tieren 🙄 haben vielversprechende Ergebnisse bei 🌩️ 🏥 #chronischentzündlichenErkrankungen des 🧠 #zentralenNervensystems und des Magen-Darm-Trakts sowie in der 🏥 🌱 #Antitumortherapie von 🤕 #Gliomen (spez. ☠️ #Hirntumor) geliefert.

https://medcan.ch/medizinische-informationen/ecs

#Medizin #Forschung #Wissenschaft #medicine #science #politics #health #Weedmob #FridaysforFUTURE #Hanfwissen #cancer #brain #antitumor #patent6630507 #neuroprotective

📢 We are glad to welcome our new #BJNANO #AssociateEditor Yohann Corvis, Université Paris Cité 🇫🇷!
He is an expert in the research on raw pharmaceutical materials including the development of #nanomedicines for anesthetic, #antitumor, and anti-inflammatory treatments, with an emphasis on #nanocrystals.

Welcome aboard Yohann!
🔗 https://www.beilstein-journals.org/bjnano/news/4GJ3JEKNEPH476ZOZEENE3LTIM?M=y

#BJNANO 💎🔓

BJNANO - New Associate Editor for the <em>Beilstein Journal of Nanotechnology</em>

New Associate Editor for the <em>Beilstein Journal of Nanotechnology</em>

#CauliflowerMushroom - #SparassisCrispa.
One of my fave #edible & #medicinal #WildMushrooms. It's found in many places around the world, including forests on #VancouverIsland.
We #forage for these wild #mushrooms & use it in making some soups & stir fry dishes.

It's used often in #traditional #Chinese #medicine #TCM because it contains active #pharmacological ingredients. In order to study its medicinal value better, the genomic sequence of S. crispa was published in Oct 2018.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207663

Dry weight of the #basidiocarp was found to contain up to 43.6% #BetaGlucan, which was approved for the treatment of #cancer in #Japan & recommended for #COVID19 patients to overcome #inflammation.

Experiments suggest that S. crispa contains chemicals that may stimulate the #ImmuneSystem & has many #biological properties including: #AntiTumor, #antiviral activity (reverse transcriptase inhibitory activity), #neuroprotection, #cardioprotection, #AntiInflammation, #hyperlipidemia, #AntiDiabetic medication, #antimicrobial compounds, & methicillin resistant Staphylococcus aureus #MRSA.

#ForestForaging #MushroomsMedicine #FoodFromTheForest #WildFoods #VanIsle #Wsanec #Saanich #PacificNorthwest #Cascadia #PNW #MushroomsMonday #LookReadLearn #AsianMastodon

Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage

Sparassis crispa (Hanabiratake) is a widely used medicinal mushroom in traditional Chinese medicine because it contains materials with pharmacological activity. Here, we report its 39.0-Mb genome, encoding 13,157 predicted genes, obtained using next-generation ...

PubMed Central (PMC)

A #YTHDF2/#m6A/NF-κB axis controls #antitumor #immunity by regulating intratumoral #Tregs

Linda Zhang, Chuan He and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113126

The powerful new substance could become the basis for #antitumor drugs because it affects the #pathology that leads to the development of malignant #tumors, such as #cancer of the #breast, #lung, #prostate, and #lymph nodes.
#Chemistry #Medical #sflorg
https://www.sflorg.com/2023/01/chm01172301.html
Chemists Created a Substance with Potential Antitumor Activity

New compound could be the basis of a drug for tumor cells

The antitumour effects of caloric restriction are mediated by the gut microbiome

https://www.nature.com/articles/s42255-022-00716-4
#cancer #microbiome #diet #Antitumor

The antitumour effects of caloric restriction are mediated by the gut microbiome - Nature Metabolism

The authors show that caloric restriction increases the intestinal abundance of Bifidobacterium bifidum, which in turn blunts tumour development in mice.

Nature
Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial

mRNA-4157/V940, in combination with KEYTRUDA, demonstrated a statistically significant and clinically meaningful reduction in the risk of disease recurrence or death compared to KEYTRUDA monotherapy in stage III/IV melanoma patients with high risk of recurrence following complete resection Results are the first demonstration of efficacy for an investigational mRNA cancer treatment in a randomized clinical trial Companies plan to discuss results with regulatory authorities and initiate a Phase 3 study in melanoma in 2023 and rapidly expand to additional tumor types CAMBRIDGE, MA and RAHWAY, NJ / ACCESSWIRE / December 13, 2022 / Moderna, Inc. (NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, and Merck (NYSE:MRK), known as MSD outside of the United States and Canada, today announced that the Phase 2b KEYNOTE-942/mRNA-4157-P201 trial of mRNA-4157/V940, an investigational personalized mRNA cancer vaccine, in combination with KEYTRUDA ® ,

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647