Fern, Frieren: Beyond Journey's End
I like that Fern goes from being a helpless child of war to a powerful mage under the tutelage of her former master, then Frieren. She's a cool-headed person, even though she constantly has to take care of everyone - like the nearly impossible task of waking up Frieren.
Poemy Watanabe, Puni Puni Poemy
A parody of a parody. Poemy-chan is just full-power silliness. Is she indestructible? Maybe. Is she headstrong? Oh yeah (but why?)! Is she destructive? Well, yes. Does she forget to stay in character and use the voice actress' real name? So often.
Kamiya Kaoru, Rouroni Kenshin
Kauru-dono is a compassionate caregiver and - while not overly skilled - still a proud ancestor of her samurai heritage. Even though she is often relegated to a you-stay-home-and-watch-the-kids sort of role, she is often the one who comes to the rescue.
Maori Mayazono, Your Lie In April
She's super talented, a good friend, and such a positive person, in spite of everything.
Maomao, Apothecary Diaries
She's smart, clever, kind, weird (I mean, who doesn't love a little poison?), and sooo cute! 
Another dreadful lack of #animegirls in my feed again. Better do what I can to help.
Here's a short thread...
今日はどっちにときめいた？内緒で教えて。
Which one made your heart skip today? Tell us in secret.
ask DNA
fontom
MissMisty