🧬 Could a new form of amyloid aggregation change how we understand Alzheimer’s disease?

🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.024

📚 CSBJ: https://www.csbj.org/

#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #AlzheimersResearch #Neuroscience #DrugDiscovery #AmyloidBeta

Lithium deficiency and the onset of Alzheimer’s disease - Nature

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Nature
Neuroscientists uncover brain changes linked to Alzheimer’s before symptoms arise

Researchers observed that amyloid-beta and tau proteins are associated with a transition from hyperactivity to slower brain activity, which aligns with declines in attention and memory, suggesting potential early indicators of Alzheimer’s disease progression.

PsyPost

https://www.nature.com/articles/d41586-023-02374-2

https://doi.org/10.1038/d41586-023-02374-2

Dementia risk linked to blood-protein imbalance in middle age

Abnormal levels of certain proteins — many of which have roles outside the brain — could be an early hallmark of Alzheimer’s disease or similar conditions.

#nature #neuroscience #neurology #dementia #alzheimers #AmyloidBeta #Tau #proteins #apolipoprotein #misfoldedproteins #proteinaggregation #immunology

Dementia risk linked to blood-protein imbalance in middle age

Abnormal levels of certain proteins — many of which have roles outside the brain — could be an early hallmark of Alzheimer’s disease or similar conditions.

Zum ersten Mal liefert ein #AmyloidBeta Antikörper (#Lecanemab) in einer großen Alzheimer Studie statistisch eindeutige Daten. Steht nach langer Zeit eine neue Zulassung bei #Alzheimer bevor?
https://www.doccheck.com/de/detail/articles/41047-alzheimer-jetzt-doch-die-demenz-weg-spritze
Alzheimer: Jetzt doch die Demenz-weg-Spritze?

Nach zwei Anläufen könnte es diesmal was werden mit dem ersten Amyloid-Antikörper, der die Progression der Alzheimer-Demenz bremst. Aber die Gretchenfrage bleibt: Wie relevant ist der Effekt?

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