📰 "Cellular-scale mechanism of cell crawling responding to substrate stiffness"
https://arxiv.org/abs/2605.07109 #Physics.Bio-Ph
#Cond-Mat.Soft
#Mechanical #Adhesion #Cell
Cellular-scale mechanism of cell crawling responding to substrate stiffness
Biological cells are able to adapt their behaviour in response to environmental cues. Durotaxis is a phenomenon in which cells adjust their migration depending on the mechanical properties of a surrounding substrate. Although durotaxis has been studied more than two decades, basic cellular-scale mechanism of how cells regulate the motility responding to substrate stiffness remains to be elucidated. We address this issue by developing a theory utilising a mechanochemical model that integrates intracellular biochemical reactions with cellular deformation and substrate adhesion. Numerical analysis reveals that the characteristic speed and diffusion constant of cells change non-monotonically with respect to substrate stiffness, indicating the emergence of an optimal stiffness for migration. In addition, by introducing a memory effect that allows feedback from cell mechanics to the intracellular chemical reactions, the persistence time increases with substrate stiffness on a substrate softer than the optimal. We further investigate theoretically the origin of the non-monotonic dependence, that is comparable to the experimental observations, in terms of cell deformation and symmetry breaking in substrate adhesion. We believe that our study provides a unifying framework to understand complex durotactic cell migration.
📰 "NCKAP1 coordinates focal adhesion and adherens junction dynamics in endothelial barrier maintenance and angiogenesis"
https://doi.org/doi:10.1016/j.isci.2026.115716https://pubmed.ncbi.nlm.nih.gov/42095096/ #Dynamics #Adhesion #Cell📰 "Adhesion-mediated transition to a mesenchymal-like, fan-shaped migration mode in Dictyostelium discoideum"
https://www.biorxiv.org/content/10.64898/2026.05.03.722454v1?rss=1 #Mechanics #Adhesion #Cell📰 "Diacerein alleviates endometrial fibrosis in an intrauterine adhesion model via ferroptosis inhibition"
https://doi.org/doi:10.1538/expanim.26-0015https://pubmed.ncbi.nlm.nih.gov/42091527/ #Mechanical #Adhesion
Diacerein alleviates endometrial fibrosis in an intrauterine adhesion model via ferroptosis inhibition
Intrauterine adhesion (IUA) is a significant contributor to uterine infertility, primarily characterized by endometrial fibrosis. Although diacerein e …
📰 "Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration"
https://doi.org/doi:10.1080/19336918.2026.2663684https://pubmed.ncbi.nlm.nih.gov/42087518/ #Dynamics #Adhesion #Cell📰 "AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration"
https://doi.org/doi:10.1038/s41467-026-72501-whttps://pubmed.ncbi.nlm.nih.gov/42082516/ #CellMigration #Adhesion #Cell📰 "Piezoelectric materials for tissue engineering and regenerative medicine: from fundamental principles to clinical applications"
https://doi.org/doi:10.1016/j.actbio.2026.04.060https://pubmed.ncbi.nlm.nih.gov/42066931/ #Mechanical #Adhesion
Rxiv mechanobio