Molecular physicist visualizes the process of dying

David Glowacki is a cross-disciplinary researcher and artist who founded the ‘Intangible Realities Laboratory’ (IRL) in Spain. A 2020 study showed that the Virtual Reality (VR) phenomenology Glowacki constructed induced peak mystical-type experiences similar to near-death and psychedelic experiences. In this conversation, Glowacki explains how his VR work led him to develop fascinating new visual metaphors for non-duality.

Essentia Foundation

This interview with Andres Gomez-Emilsson is about 45 minutes too long and the title is misleading, but there are some interesting tidbits, observations, and speculation about the #phenomenology of #psychedelic experiences here.

https://youtu.be/gi08eVU_-f8

#psychedelics #DMT #5MeODMT #psilocybin

DMT Entities Decoded by Coupled Oscillators

YouTube
Current evidence for the role of rapid-acting antidepressants (RAAD) in bipolar depression? A perspective and plan for action - PubMed

After decades of limited progress in depression treatment, recent advancements have sparked renewed interest in developing novel antidepressants, particularly rapid-acting antidepressants (RAADs). Despite these promising developments, there remains a significant gap in research on bipolar depression …

PubMed
https://journals.sagepub.com/doi/10.1177/02698811241246857 Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine benzoate) in healthy participants (Rucker, et al, 2024) — in which they test intranasal #5meodmt and report resulting #psychedelic mystical experiences having clinical potential. This change in #consciousness often ignored in #psychedelics #mdma and #ketamine research #fda
https://www.beckleypsytech.com/posts/first-participant-dosed-in-research-study-investigating-effects-of-5-meo-dmt-on-human-brain First participant dosed in research study investigating the effects of BPL-003, a novel formulation of #5meodmt on the human brain with psychological support. #psychedelic #psychedelics #psychedelicassistedpsychotherapy #psychedelicresearch #psychedelictherapy
First participant dosed in research study investigating the effects of BPL-003, a novel formulation of 5-MeO-DMT, on the human brain

The study is the first of its kind to assess the effects of 5-MeO-DMT in the human brain and will investigate the neurophysiological effects of BPL-003, Beckley Psytech’s novel synthetic intranasal formulation of the psychedelic 5-MeO-DMT. In the study, healthy volunteers will be given both placebo and a 12 mg dose of BPL-003 on separate study visits over a period of 1 month while undergoing a high-density electroencephalogram (HD-EEG) scan to measure the electrical activity in the brain in order to better understand how 5-MeO-DMT elicits its profound consciousness-altering effects. The trial is being overseen by Dr. Christopher Timmermann and Dr David Errtizoe from the Centre for Psychedelic Research at Imperial College London and is funded through a research grant from Beckley Psytech. Initial results are expected in 2026.

#psychedelictherapy is #existential and that doesn't just happen safely within the walls of a psychotherapy office or psychedelic center. #telehealth increases access to #psychedelicassistedpsychotherapy in all 50 states #psychedelicmedicines have been studied as adjuncts to psychotherapy for over 100 years. #mdma was first synthesized in 1912 by Merck. #psychedelicresearch in #psychedelics ranging from #LSD to #mdma #ketamine #dmt #ayahasuca #5meodmt #mescaline #psilocybin spans 100 years.
https://www.nature.com/articles/s41586-024-07403-2 Structural pharmacology and therapeutic potential of 5-methoxytryptamines (Warren, et al, 2024) #5meodmt #psychedelic #psychedelics #depression #psychedelicresearch #psychedelictherapy
Structural pharmacology and therapeutic potential of 5-methoxytryptamines - Nature

Detailed analyses of the serotonin receptor 5-HT1A and the psychedelic 5-methoxy-N,N-dimethyltryptamine reveal the differences in receptor structural pharmacology that mediate signalling specificity, efficacy and potency, findings that may facilitate the development of new neuropsychiatric therapeutics.

Nature
Unlimited Sciences - The power of US

The power of US Collective research exploring the unlimited potential of psychedelics Unlimited Sciences is a nonprofit organization that conducts real-world psychedelic research and provides cost-free direct support to those wanting to learn more about psychedelics. We believe everyone should be empowered to safely take their health into their own hands. Whether you’re seeking help, […]

Unlimited Sciences