Brain signatures of rare variants hint at cardiovascular risk
People whose brains look like those of people who carry autism-linked copy number variants also share markers of heart health.
Protein networks identified in autism-linked genetic deletion | Spectrum | Autism Research News
The OTUD7A gene, which may account for some traits in people missing a segment of chromosome 15, appears to interact with several known autism-linked genes.
Single gene insufficient to account for dup15q, Angelman traits | Spectrum | Autism Research News
UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.
Consistent, convergent pathways link two forms of autism | Spectrum | Autism Research News
People with dup15q syndrome and those with idiopathic autism have similar patterns of altered gene expression in early brain development and later in life.
Autism’s genetic heterogeneity evident in brain connectivity patterns | Spectrum | Autism Research News
The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.
Lumping versus splitting with autism-linked variants: A conversation with Vanessa Vogel-Farley and Yssa DeWoody | Spectrum | Autism Research News
Researchers have long studied subgroups of people who share genetic variants, but the newly formed ‘CNV Commission’ is also looking at people with shared traits across different neurodevelopmental conditions.
Autism and the complete human genome: Q&A with Evan Eichler | Spectrum | Autism Research News
Researchers have filled in missing swaths of the human genome — an advance likely to inform every aspect of autism genetics research, Eichler says.
One-shot gene therapy for Angelman syndrome shows promise in mice | Spectrum | Autism Research News
A potential new gene therapy delivered via a single injection mimics ratios of proteins normally found in cells.
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin | Spectrum | Autism Research News
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Autism News International